Archive for December, 2008

3G Broadband To Bring High-Speed Internet To Emerging Markets

Sunday, December 14th, 2008

Dec 12, 2008 4:19 PM, MD&D News Staff

Qualcomm has announced a PC alternative designed to make high-speed Internet access more widely available and affordable in emerging markets. The Kayak PC alternative leverages the widespread availability of 3G wireless broadband to bring Internet connectivity to markets where wired Internet access has often been difficult to access or unaffordable. According to Qualcomm, Kayak fills the niche between desktop PCs, which normally require landlines or separate accessories for connectivity, and Internet-capable wireless devices.

Kayak’s reference design and recommended software specifications will be available to device manufacturers. The reference design uses Qualcomm’s dual-core Mobile Station Modem MSM7xxx-series chipsets to provide computing and connectivity. Devices based on the reference design will offer a full-featured Web 2.0-capable browser from Opera Software than can perform at desktop resolutions, as well as access via the browser to Web 2.0 productivity applications. (more…)

3G Wi-Fi Routers Get Smaller, Sexier

Sunday, December 14th, 2008

Novatel’s new MiFi — gets smaller, offers storage
10:28AM Saturday Dec 13 2008 by Karl Bode

Portable 3G to Wi-Fi routers have been around for a while, allowing you to share your 3G connection while on the move — assuming you don’t bump into your 3G carrier’s monthly cap.

The devices are certainly getting smaller and sexier — Novatel’s MiFi getting oodles of press this week for being quite the looker. The device, set to be released early next year for less than $200, offers HSDPA and EVDO to Wi-Fi bridging with a battery that can handle up to 4 hours of use (and 40 hours of standby). (more…)

HIV/AIDS charity to host free dinner, fashion show

Sunday, December 14th, 2008

UNION-TRIBUNE
7:09 a.m. December 12, 2008

NORTH PARK: A charity that helps Latinos with HIV/AIDS will host a Christmas celebration at 6 p.m. today in North Park.

The event, by Bienestar – Spanish for well-being – will include a free dinner, a drag queen fashion show and a vigil for those affected by HIV. It will be held at the agency’s offices, 3020 North Park Way. The federal Centers for Disease Control and Prevention is providing the funding. (more…)

Cancer to Surpass Heart Disease as World’s Leading Killer

Sunday, December 14th, 2008

By Steven Reinberg
HealthDay Reporter

TUESDAY, Dec. 9 (HealthDay News) — By 2010, cancer will be the leading killer in the world, surpassing heart disease, causing more deaths than AIDS, malaria and tuberculosis combined.

Unless new treatments are found, there could be 27 million people with cancer by 2030, and 17 million cancer deaths annually. And, there could be 75 million people living with cancer within five years after diagnosis, according to a new report, 2008 World Cancer Report, released Tuesday by the World Health Organization.

“The burden of cancer is shifting from developed countries to developing nations,” Dr. Otis Webb Brawley, chief medical officer of the American Cancer Society, said during a teleconference. “And with a growing and aging population, we must take steps to address this problem now.” (more…)

Breast Cancer: Research On Tamoxifen Leads To Recommendation For CYP2D6 Gene Test

Sunday, December 14th, 2008

ScienceDaily (Dec. 13, 2008) — Findings from a new study have prompted Mayo Clinic researchers to recommend CYP2D6 gene testing for postmenopausal women about to begin tamoxifen therapy. This data confirms that women with an inherited deficiency in the CYP2D6 gene, which is important for the metabolism of tamoxifen, have a nearly fourfold higher risk of early breast cancer recurrence compared to women who have not inherited the deficiency.

The research findings, announced jointly by investigators from Mayo Clinic and the Austrian Breast and Colorectal Cancer Study Group (ABCSG) confirmed results from a previous study conducted by Mayo Clinic. The latest findings will be presented December 13 at the Cancer Therapy & Research Center-American Association for Cancer Research (CTRC-AACR) 31st annual San Antonio Breast Cancer Symposium. (more…)

Gene Test Better Predicts Breast Cancer Risk

Saturday, December 13th, 2008

DNA

New Tool Looks for Gene Variations linked to Increased Risk
By Charlene Laino
WebMD Health NewsReviewed by Brunilda Nazario, MD

Dec. 12, 2008 (San Antonio) – A new genetic test is much better at predicting breast cancer risk than the standard model, researchers report.

The new test, known as OncoVue, looks at variations in 19 genes associated with breast cancer risk, says Kathie Dalessandri, MD, a breast cancer researcher at the University of California, San Francisco.

Currently, doctors use the Gail model to determine a woman’s chance of developing breast cancer. It evaluates five personal and family predictors of breast cancer risk — age, age at first period, number of breast biopsies performed, age at the birth of first child, and number of immediate relatives who have had breast cancer. (more…)

DNA Repair Company Announces New Clinical Findings Which May Help to Guide Breast Cancer Treatment

Saturday, December 13th, 2008
BOSTON, Dec 12, 2008 (BUSINESS WIRE) — The DNA Repair Company (DNAR), an early-stage company focused on personalized approaches to cancer treatment, announced today that it has identified a promising set of protein biomarkers that may aid in the treatment of a particularly aggressive form of breast cancer. These findings were presented at the CTRC-AACR San Antonio Breast Cancer Symposium.
The DNAR study was conducted in collaboration with investigators from the Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center, both in Boston. The lead author of the study, Brian Alexander, MD, physician resident at the Harvard Radiation Oncology Program and currently a White House Fellow, was selected as a recipient of the prestigious AstraZeneca Clinical Scholars Award in recognition of the merits of the study.
The study was conducted using clinical data with so-called “triple-negative” breast cancer, a form of the disease that is not responsive to therapies targeting estrogen receptors, progesterone receptors, or the HER2 receptor. The prognosis for triple-negative breast cancer is poor, due in part to the more limited set of treatment options available.
Clinical biopsies from 143 patients were examined to determine whether the modulation of various DNA repair proteins might have an impact on disease progression. DNA repair pathways correct DNA that has been damaged by many common forms of cancer treatment (e.g. chemotherapy and radiation) and play a central role in making tumors resistant to therapy.
With clinical samples from half of the patients, the investigators discovered a statistically significant correlation between the presence of four DNA repair proteins and recurrence-free survival. Investigators were then able to validate the correlation with progression-free survival seen in this cohort by testing the four proteins in the second group of patients. The marker panel distinguished a high risk group of patients with a medium time to recurrence of 14 months from low risk patients with median time to recurrence of >10 years. Even though a number of DNA repair markers produced statistically significant results individually, results observed with the four DNA repair marker panel were superior to those seen with a number of single markers.
These findings are significant, because they suggest that monitoring DNA repair protein profiles in patients with triple-negative breast cancer will contribute important insights as prognostic or predictive tools. In addition, DNA repair pathways may provide a promising target for developing novel therapies for the disease.
“These findings provide intriguing evidence that the activity of certain DNA repair pathways play an important role in determining how patients with triple-negative breast cancer will respond to therapy, and further validation will help focus drug development on approaches most likely to succeed,” said lead investigator Judy E. Garber, MD, MPH, Director of the Cancer Risk and Prevention Program at Dana-Farber and Associate Professor of Medicine, Harvard Medical School. “The frequently poor prognosis for patients with this form of breast cancer lends increased urgency to understanding the molecular basis of the disease, and its implications for treatment and new drug development.”
About DNAR
DNAR is leveraging its deep knowledge of the role that DNA repair pathways play in cancer to create new tools that give physicians unprecedented data-driven insights into which course of treatment will work most effectively for an individual patient. DNAR aims to improve patient care by improving physicians’ ability to prescribe the most effective treatments the first time from the host of therapeutic options available. DNAR is advancing a major goal of personalized medicine – to identify the right therapy for the right patient, and to reduce the need for “trial and error” medicine.
SOURCE: The DNA Repair Company

DNA analysis helps solve vehicle burglaries

Saturday, December 13th, 2008

DNA evidence helped Carencro police solve a string of 12 vehicle burglaries, the Police Department said.

Travis Amy, 27, of Dequincy, an inmate at the J.B. Evans Correctional Institute in Tensas Parish, has been charged with vehicular burglary in the crimes.

Investigators sent blood left at the crime scenes to the Acadiana Crime Lab. The Police Department said the lab matched the DNA pattern to Amy in April. Another blood sample, taken from Amy, confirmed the match, police said.

The investigation lasted a year and half. Amy will remain at Evans until his extradition to Lafayette, police said.

LAFAYETTE

‘Christmas for Kids’ at the Outreach Center

Home Bank and Stirling Properties have partnered with the Outreach Center again this year to help make Christmas special for more than 300 disadvantaged children by hosting Christmas for Kids. This year’s event will be held on the Center’s campus from 10:30 a.m. to 1 p.m. today.

It will help provide those families in need with gifts for their children on Christmas morning.

While the parents are loading up the toys collected by the U.S. Marine Corps’ Toys for Tots, the pre-registered children 12 years of age and younger will be treated to a holiday party.

The children will have the opportunity to take a picture with Santa and make it into an ornament or a magnet to give as a gift to their parents.

For more information, call Jesse Guidry at 237-7618 or go to acadianaoutreach.org.

Part of Barry Street to close this weekend

The 100 block of Barry Street will be closed through midnight Sunday as First Baptist Church will hold Festival de Noel.

Detour routes will be made available.

Inmate cleared by DNA freed on bond

Saturday, December 13th, 2008

By JUAN A. LOZANO Associated Press Writer
Dec. 12, 2008, 7:35PM

HOUSTON — A Houston man who spent five years in prison for the sexual assault of an 8-year-old boy was freed Friday after DNA evidence which had gone untested until recently showed he didn’t commit the crime.

Ricardo Rachell did not stop to talk to reporters after he walked out of the Harris County Jail Friday evening. But Rachell’s sister said his family always believed he was innocent.

“The whole family is very glad he’s been exonerated,” said Phyllis Glenn as she whisked her brother into a waiting car. “It’s a day we’ve been waiting for.”

Earlier on Friday, a judge approved a personal recognizance bond for Rachell so he could be free while his attorney begins the legal process required to overturn a 2003 conviction on aggravated sexual assault. Rachell, 51, was transferred from a state prison to the Harris County Jail earlier this week.

He did not appear at a brief court hearing where he was given a bond. Rachell waited about eight hours after the bond was approved for his paperwork to be processed and his family to drive in from suburban Houston to pick him up.

He has served five years of a 40-year sentence.

“This is a horrible mischaracterization of justice I think on everybody’s part,” said Deborah Summers, Rachell’s attorney. “It’s this kind of case that really is frightening for our system.”

Summers said she plans to file paperwork to both overturn Rachell’s conviction and ask for a pardon, which the Harris County District Attorney’s Office has indicated it will support.

In the case, the victim was taken to a vacant house and sexually assaulted after being told by the man that he would pay him for help with removing some trash. The next day the boy’s family called police and the child identified Rachell.

Although DNA from both the attacker and Rachell was collected after the 2002 attack, no tests were ever performed.

Roe Wilson, chief of the district attorney’s legal services bureau, said the DNA evidence was never tested because the boy and a young companion both identified Rachell as the attacker. Wilson said it was a mistake not to test the evidence.

“Our office is being very candid. We should have requested the testing,” she said. “There was what we thought was strong eyewitness identification.”

Summers said she can’t understand how Rachell was misidentified because he has a very distinctive appearance; his face was disfigured in a shotgun accident years ago, which also makes it difficult for him to speak.

“He’s not the kind of person you would mistake,” she said. “This is a case where no one would have believed he would be misidentified because there is just no way. There was never any wavering in the identification. But how could you misidentify this guy?”

Summers, who was not Rachell’s trial attorney, said she doesn’t know if his facial disfigurement was ever brought up at trial.

“Before the arrest, the victim and the other boy described him as having something wrong with his face,” Wilson said. “When he was identified it seemed at the time to make sense.”

Rachell always maintained his innocence and was vehement there was DNA in his case that was never tested, Summers said.

“I said, ‘I don’t think there was because everybody kept telling me there wasn’t,'” she said.

Summers said there was mention of a rape kit in the offense report but she didn’t know what happened to it. The evidence — clothing and medical swabs — was finally found in February, more than a year after Rachell and his attorney filed a request with the state for DNA testing of it.

The testing was completed Oct. 28 and it identified the attacker as being another man who is a known sex offender, Summers said.

Rachell’s case is among about 540 that have been reviewed — or are currently under review — by the district attorney’s office since 2001. Many reviews were prompted because of problems with the Houston Police Department’s crime lab, which has been under scrutiny since 2002, when its DNA section was first shut down. Inaccuracies were later found in four other lab divisions that test firearms, body fluids and controlled substances.

Three inmates have been released from prison because of mistakes by the lab.

But Rachell’s case is different from those because it wasn’t a situation where testing was performed and it was wrong or improperly done.

His attorney said she believes this case is more egregious.

“I don’t know what happened here but it was unbelievably unfair,” Summers said.

Apple App Store’s greatest strength also its biggest downfall

Saturday, December 13th, 2008

One of the greatest things about the iPhone App Store is that the barrier to entry is pretty low. This means anyone with some solid coding skills and a good idea can hop in. Apple takes care of the hosting, the credit card authorization and even some of the marketing.

But this is also one of the downfalls of the App Store. It is too easy to create something that is a) not fun or useful or b) a copy of someone else’s work, done on the cheap and sold at a lower price.

The lower-quality apps are usually fettered out in the comments and ratings on the App Store, however. Even if an app sounds interesting, low ratings usually dissuade users from jumping in. This begins a downward spiral that bad games rarely get out of, even after updates.

The bigger problem is the copying of applications. Take for instance,2across, the crossword puzzle app from Eliza Block (iTunes link). When it came out, there was only one other crossword puzzle application. There was plenty of market for both of them. Now it appears that there are 10-30 apps in the marketplace. Some of them look cobbled together from other platforms, or from scratch but very quickly. They are also cheap, some ‘selling’ for free and being supported by ads. Add to this the larger companies who see a success and jump in with similar apps and app functionality with their larger marketing budgets and it isn’t such a boon for independent developers anymore.

Eliza has taken to making a free, partially disabled (only three sources can be used) version of her application. She’s also upgrading her application to work in different languages and reach a wider audience.

This won’t help much with the crossword game market saturated. Her game gets great reviews but so do lots of others. Obviously, she’s not making the kind of money she made when she had a virtual monopoly on the space.

A pricing model is starting to develop seen by the maturity of the market.

  • $5.99 – 9.99 – This is where applications usually start.
  • $4.99? – If a new competitor enters a market, apps developers often lower their prices to differentiate themselves.
  • $1.99 – $3.99 – Once price wars start and other competition enter the market, companies need to stay low to survive
  • $.99 – Developers are forced into this lowest price group if they still want to make money.? The majority of paid apps are in this lowest group.? Developers aren’t terribly happy about this.
  • Free/ad supported – Some developers just give a partially disabled version of their app away hoping to entice users to upgrade to a more expensive version later.? Other companies try to eek out some money with Google Adsense.? While this is a low upfront money maker, if the game is popular and lends itself well to ads, there is a long stream of micropayments that could last years.

So what to do?? Eliza is already at work on her second game, one that she thinks will be copied less because it won’t have as diverse an audience. Security through obscurity?

Innovation is an obvious answer.? There aren’t many others.?

In this case there is a silver lining/happy ending: She got a “very exciting” job offer from Apple which commences in 2009.